International Journal of Pharmaceutics & Drug Research

Kumare Vaishnavi Ramesh, S. D. Mahajan, Sachin B Dudhe

ABSTRACT

This research focused on the development and characterization of sustained-release sublingual tablets containing Metoclopramide, a medication widely used for managing nausea and vomiting. The formulation process involved a comprehensive evaluation comprising pre-compression and post-compression assessments to ensure the tablets' optimal physical and pharmacokinetic properties. Pre-compression studies encompassed various parameters such as bulk density, tapped density, compressibility index, and Hausner ratio. Post-compression analysis included measurements of tablet thickness, hardness, weight variation, friability, and drug content uniformity. These parameters are essential indicators of tablet robustness, integrity, and drug content consistency for ensuring the tablets' efficacy and safety during storage and administration. In-vitro drug release studies were conducted to assess the tablets' performance over time and to establish their sustained-release profile. Regression analysis data were employed to elucidate the drug release kinetics from the tablets. The zero-order, first-order, Higuchi, and Korsmeyer-Peppas models were applied to the release data, providing valuable insights into the underlying drug release mechanisms and kinetics. Among the formulations evaluated, formulation F3 emerged as the optimized formulation based on its superior characteristics, including consistent drug release, favorable swelling behavior, and adherence to first-order drug release kinetics. These findings highlight the potential of sustained-release sublingual tablets of Metoclopramide as a promising dosage form for improving patient compliance and therapeutic outcomes in the treatment of nausea and vomiting.

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