FORMULATION AND EVALUATION OF MUPIROCIN LOADED INVASOMES FOR EFFECTIVE TREATMENT OF SKIN INFECTIONS
Krishna Chandra, Sandesh Asati, Shailendra Lariya
ABSTRACT
This study aimed to formulate and evaluate Mupirocin-loaded invasomes for the effective treatment of skin infections. Invasomes were prepared using Soya Phosphatidylcholine and evaluated for vesicle size, entrapment efficiency, drug content, and in-vitro drug release. Six formulations (F1 to F6) were prepared, with formulation F3 showing optimal characteristics: vesicle size of 359.58 nm, entrapment efficiency of 85.29%, and drug content of 98.28%. In-vitro drug release studies indicated sustained release of Mupirocin from formulation F3, following the Korsmeyer-Peppas model. These results demonstrate the potential of invasomes as a carrier system for improving the therapeutic efficacy of Mupirocin in treating skin infections.
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