FORMULATION AND EVALUATION OF ALOIN LOADED MICROSPONGES GEL FOR WOUND HEALING ACTIVITY
Manvendra, Akhlesh Kumar Singhai, Mahadev Kanere
ABSTRACT
The study aimed to develop and evaluate an aloin-loaded microsponges gel for enhanced wound healing activity. Aloin, a potent bioactive compound, was successfully encapsulated in microsponges using the quasi-emulsion solvent diffusion method. The microsponges were characterized for particle size, zeta potential, and entrapment efficiency, with formulation F2 showing optimal properties: a particle size of 498.5 nm, zeta potential of -2.3 mV, and entrapment efficiency of 91.09%. The microsponges were incorporated into a gel base and evaluated for physical appearance, pH, viscosity, and spreadability. The in vitro release study indicated a sustained release pattern following Higuchi kinetics, with 97.05% drug release over 9 hours. The developed aloin-loaded microsponges gel exhibited excellent wound healing potential, making it a promising candidate for future clinical applications.
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