ANTI-DIARRHEAL ACTIVITY OF POLYHERBAL FORMULATION OF TAMARINDUS INDICA AND WOODFORDIA FRUTICOSA LEAVES EXTRACT
Reetu Sahu, Sandra Goutam, B.K. Dubey, Deepak Kumar Basedia, Mukesh Kumar Patel
ABSTRACT
The present study investigated the anti-diarrheal activity of a polyherbal formulation (PHF) consisting of ethanolic extracts of Tamarindus indica and Woodfordia fruticosa leaves. The extracts were evaluated for their consistency, color, and phytochemical composition, revealing the presence of carbohydrates, tannins, alkaloids, glycosides, flavonoids, and proteins. The anti-diarrheal efficacy of the PHF was assessed using an animal model, where it significantly delayed the onset of diarrhea and reduced the total number of faecal drops and frequency of diarrhea. The PHF at doses of 100 mg/kg and 200 mg/kg exhibited dose-dependent protection against diarrhea, with the higher dose showing greater efficacy. The results suggest that the PHF has potential therapeutic benefits for treating diarrhea, likely due to the synergistic effects of its bioactive compounds. Further studies are warranted to elucidate the mechanisms of action, optimal dosage, and clinical relevance of the PHF.
[Full Text Article]