FORMULATION AND EVALUATION OF NANOSPONGES CONTAINING HYDROGEL OF HYDROQUINONE AND ALOIN
Aastik Shankar, Akhlesh Kumar Singhai, Steffi Thomas
ABSTRACT
Nanosponge loaded gels are novel drug delivery system that combines the advantages of achieving optimum concentration of drug at site of action and reduction in systemic side effects. The objective of the present study was to formulate and evaluate gel loaded with nanosponges containing Hydroquinone and aloin for topical delivery. Hydroquinone and aloin nanosponges were prepared successfully using ethyl cellulose as polymer, polyvinyl alcohol as cross-linking agent and dichloromethane as solvent by solvent evaporation technique, which undergo analysis of drug entrapment efficiency, SEM, particle size analysis and zeta potential. Among all 5 different formulations, F2 batch was considered as the best with 80.03% of drug entrapment efficiency and least particle size. From the SEM analysis it was found that nanosponges are spherical with smooth surface. The nanosponge of the best formulation F2 was loaded into the Carbopol gel which was evaluated for viscosity, spreadability, pH, drug content, in vitro drug release study and stability studies. From the study it was found that the prepared Hydroquinone and aloin nanosponge topical gel shows promised drug release and good stability.
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