REVIEW ON ANIMAL MODEL FOR DEMENTIA ASSOCIATED DISEASE
Sanskar Jain, Samrat Biswas, Sameer Khan, Rohit Sahu, Rituraj Singh Lodhi, Sunayana Kesharwani
ABSTRACT
Dementia-associated diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative disorders, represent a significant burden on global health. To advance our understanding and develop effective treatments, animal models have been extensively utilized. These models, ranging from invertebrates like Caenorhabditis elegans and Drosophila melanogaster to vertebrates such as rodents and non-human primates, offer invaluable insights into the pathophysiology of dementia. Transgenic rodent models, in particular, have been instrumental in elucidating the genetic and molecular mechanisms underlying AD and PD, by replicating human-like amyloid-beta plaque formation, tau protein tangles, and alpha-synuclein aggregation. Additionally, these models are pivotal for preclinical drug testing and biomarker discovery. Despite their contributions, limitations such as differences in brain structure and function between humans and animals, and the complexity of human dementia, necessitate continuous refinement of these models. Future directions include the development of more sophisticated models that better mimic human disease pathology and the integration of multi-species data to enhance translational relevance.
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