DEVELOPMENT & CHARACTERIZATION OF VANCOMYSIN COLON TARGETING NANOSPONGES FOR TREATMENT OF COLITIS
Ameer Hamza, B. K. Dubey, Deepak Kumar Basedia, Mukesh Kumar Patel, Sunil Shah, Vivek Singh Thakur
ABSTRACT
In this study, Vancomycin-loaded nanosponges were developed and characterized for their potential application in the treatment of colitis. Colitis, characterized by inflammation of the colon, poses significant challenges in treatment due to the need for targeted drug delivery to the inflamed tissues while minimizing systemic side effects. Nanosponges are emerging as promising drug delivery systems due to their ability to encapsulate drugs, protect them from degradation, and provide controlled release profiles. The nanosponges were prepared using a polymer-based method and characterized for various physicochemical properties. The formulations (F1-F6) were evaluated for poured density, tapped density, Carr’s index, and Hausner’s ratio to assess their flow properties and compressibility. The results showed that the nanosponges exhibited good flowability and compressibility, essential for uniform dosing. The developed Vancomycin-loaded nanosponges showed promising characteristics for targeted delivery to the colon. They exhibited high drug loading efficiency, appropriate particle size, good stability, and controlled release profile. These findings suggest that Vancomycin nanosponges could be a viable therapeutic option for the treatment of colitis, offering localized drug delivery and minimizing systemic side effects.
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