International Journal of Pharmaceutics & Drug Research

Saurabh Tomar and Akash Sharma

ABSTRACT

Cordia dichotoma belonging to the family Boraginaceae. Cordia dichotoma is commonly present in tropical and subtropical regions. It grows in the sub-Himalayan tract and outer ranges, ascending up to about 1 500 m elevation. It is found in divers of forests ranging from the dry deciduous forests of Rajasthan to the moist deciduous forests of Western Ghats in India and tidal forests in Myanmar. Several chemicals have been identified from seeds of C. dichotoma. The seed contains ?-amyrins, betulin, octacosanol, lupeol-3rhamnoside, ?-sitosterol, ?-sitosterol-3glucoside, hentricontanol, hentricontane, taxifolin-3-5-dirhamnoside, hesperitin-7-rhamnoside and Fatty acids such as palmitic acid, stearic acid, arachidic acid, behenic acid, oleic acid and linoleic acid. Four flavonoid glycosides (robinin, rutin, rutoside, datiscoside and hesperidin), a flavonoid aglycone (dihydrorobinetin) and 2 phenolic derivatives (chlorogenic acid and caffeic acid) were isolated from seeds. Diabetic neuropathies are a family of nerve disorders caused by diabetes. People with diabetes can, over time, develop nerve damage throughout the body. Some people with nerve damage have no symptoms. Others may have symptoms such as pain, tingling, or numbness loss of feeling in the hands, arms, feet, and legs. Nerve problems can occur in every organ system, including the digestive tract, heart, and sex organs. The present study was performed to evaluate the potency and effect of ethanolic extract of Cordia dichotoma in Diabetic neuropathy. Thus, it can be concluded from our findings that the levels of Glucose, total serom protein, urine protein levels, which are actually raised in Diabetic neuropathy can be lowered with Ethanolic extract of Cordia dichotoma. Two doses were given to chosen animal model and dose at 200mg/kg has shown its significant effect. Further studies on the extract and/or its chemical constituents are needed to pinpoint the findings. This report may serve as a footstep on this aspect and conclusion

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