FORMULATION AND CHARACTERIZATION OF EUDRAGIT NANOSUSPENSION FOR OCULAR DELIVERY OF INDOMETHACIN
Reshu Jain, Chhaya Chadhar, Shubham patel, Ravindra Balmiki, Dr. Manish Dubey,
Dr. Shailendra Patil.
ABSTRACT
The aim of this study is to formulate a novel ocular Nanosuspension (ONS), an alternative carrier system to traditional colloidal carriers for controlled release (CR) of Indomethacin (IM) .In the present study, ONS is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half-life by increasing efficiency of drug encapsulation as well as by CR. A quassi-emulsion solvent evaporation method was used to prepare IM loaded Eudragit RS 100 ONS with the aim of improved ocular bioavailability and distribution. Five different formulations were prepared and evaluated for pH of ONS, particle size, entrapment efficiency, differential scanning Caloritmetry (DSC), in vitro release profile, in vivo release studies and stability studies. An average size range of 50 to 500 nm in diameter was obtained and encapsulation efficiency up to 96.0% was observed for all the formulations. Cumulative percent drug released for all the formulation after 14 h was between 86.24 to 96.18% indicating effective CR property of ONS. The release profile revealed from best formulations followed Non- Fickian diffusion mechanism.
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