FORMULATION AND CHARACTERIZATION OF GASTRORETENTIVE MICROSPHERE OF FAMOTIDINE
Achal Janardhan Chavhan, S. D. Mahajan, Sachin B Dudhe
ABSTRACT
This research focuses on the development and evaluation of gastroretentive microspheres of Famotidine, a drug used in the treatment of peptic ulcers. Gastroretentive drug delivery systems aim to prolong the residence time of drugs in the stomach, thereby improving their absorption and bioavailability. Microspheres, owing to their controlled release and ease of formulation, serve as a promising platform for drug delivery. The study involves the formulation of Famotidine-loaded microspheres using various polymers and cross-linking agents. Characterization of these microspheres includes assessment of particle size, morphology, drug loading, and release kinetics. The comprehensive analysis presented in this study provides insights into the formulation and evaluation of Famotidine floating microspheres, offering potential for enhanced therapeutic outcomes in the management of peptic ulcers.
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