METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF EFONIDIPINE HYDROCHLORIDE AND METOPROLOL SUCCINATE USING HYDROTROPIC AGENTS
Vipin Kumar Singh, Muraree Lal, Avinash Krishnarao Kondalkar
ABSTRACT
This study presents the development and validation of a method for the simultaneous estimation of Efonidipine Hydrochloride (EDH) and Metoprolol (MPL) using hydrotropic agents. Solubility enhancement is important aspect in the analysis of these drugs, and hydrotropic agents offer a cost-effective and environmentally friendly solution. The method development involved the optimization of hydrotropic agents such as urea and sodium acetate to improve solubility and facilitate simultaneous quantification. Validation parameters including accuracy, precision, specificity, linearity, and robustness were evaluated to ensure the reliability and suitability of the method for analytical purposes. The validated method offers practical utility for quality control laboratories, pharmaceutical industries, and regulatory agencies involved in the analysis of EDH and MPL formulations, streamlining the analysis process and supporting comprehensive quality assessment.
[Full Text Article]