ASSESSMENT OF ANTI-ARTHRITIC EFFECT OF THE NYCTANTHES ARBOR-TRISTIS
Yogesh Patel, Harshita Jain, Arpit Shrivastava, Prateek Kumar Jain
ABSTRACT
Nyctanthes arbortristis, commonly known as "Harsingar" or the Night-flowering Jasmine, is a plant with a rich history in traditional medicine. In this study, a hydroalcoholic extract of Nyctanthes arbor-tristis leaves was prepared, and its phytochemical composition was analyzed. Additionally, the in-vitro anti-arthritic activity of the extract was assessed using the bovine serum protein denaturation method. The hydroalcoholic extract of Nyctanthes arbor-tristis leaves was subjected to phytochemical analysis to identify the presence of bioactive compounds. Various phytoconstituents such as alkaloids, flavonoids, terpenoids, tannins, and glycosides were evaluated. The anti-arthritic potential of the extract was investigated using the bovine serum protein denaturation method. This method is a widely used in-vitro assay to assess the ability of substances to inhibit protein denaturation, a process associated with inflammatory conditions. The phytochemical analysis revealed the presence of alkaloids, flavonoids, terpenoids, tannins, and glycosides in the hydroalcoholic extract of Nyctanthes arbor-tristis leaves. These bioactive compounds are known for their potential therapeutic effects. In the in-vitro anti-arthritic activity assay, the extract demonstrated a significant inhibition of bovine serum protein denaturation. This suggests a potential anti-inflammatory effect, indicating the extract's ability to interfere with processes associated with arthritis. The hydroalcoholic extract of Nyctanthes arbor-tristis leaves showed promising anti-arthritic activity in the in-vitro assay. The presence of bioactive compounds known for their anti-inflammatory properties supports the traditional use of Nyctanthes arbor-tristis in managing arthritic conditions.
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