ENHANCEMENT OF SOLUBILITY AND DEVELOPMENT OF ORODISPERSIBLE TABLETS OF ANTIHYPERTENSIVE DRUG
Rupesh Kumar Kushwaha, Avijeet Jain, Sunil Kumar Shah, Mukesh Kumar Patel,
B. K. Dubey, Deepak Kumar Basedia
ABSTRACT
This study aimed to enhance the solubility and develop orodispersible tablets of an antihypertensive drug Irbesartan, addressing the challenge of poor solubility often encountered with such medications. Solid dispersion formulations were prepared using different ratios of the drug and PEG 4000, a polymer known for its solubilizing properties. Evaluation of solubility enhancement revealed that the 1:3 ratio of drug to PEG 4000 exhibited the highest percentage enhancement, indicating the effectiveness of solid dispersion formulations. Subsequently, optimized orodispersible tablets were developed based on evaluations of compressibility, disintegration time, and dissolution behavior. Formulation F7 emerged as the optimized formulation, demonstrating the shortest disintegration time and rapid drug release. In vitro dissolution testing showed that increasing the concentration of disintegrant led to higher drug release rates, with solid dispersion technology significantly enhancing the dissolution rate and efficiency of the antihypertensive drug. Overall, the developed orodispersible tablets hold promise for improving the oral delivery of the antihypertensive drug, offering rapid disintegration and efficient drug release kinetics. This research contributes to addressing the solubility challenges associated with antihypertensive medications, potentially enhancing patient compliance and therapeutic outcomes
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