IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

SIMPLE COST EFFECTIVE METHOD DEVELOPMENT FOR THE ESTIMATION OF ISOCONAZOLE BY USING UV AND HPLC

Ramkumar Uikey, Vivek Thakur, B. K. Dubey, Deepak Kumar Basedia

ABSTRACT

Isoconazole is a potent antifungal agent used in the treatment of various fungal infections. The accurate estimation of isoconazole for ensuring the quality and efficacy of pharmaceutical formulations containing this drug. In this study, we aimed to develop simple and cost-effective methods for the estimation of isoconazole using UV spectrophotometry and HPLC. The UV spectrophotometric method demonstrated good linearity over the concentration range of 2-10 ?g/ml, with a correlation coefficient (r2) of 0.997. Meanwhile, the HPLC method exhibited a correlation coefficient of 255.5, indicating its suitability for isoconazole quantification. Both methods were further evaluated for accuracy through recovery studies at different concentration levels (80%, 100%, and 120%), yielding satisfactory results. Precision studies were conducted to assess the repeatability, intermediate precision, and reproducibility of the UV and HPLC methods. The results confirmed the reliability and consistency of both methods in quantifying isoconazole. Additionally, the assay of tablet formulations using these methods demonstrated accurate quantification of isoconazole content, further validating their suitability for routine quality control analysis. In conclusion, the developed UV and HPLC methods offer reliable options for the estimation of isoconazole in pharmaceutical formulations. These methods are simple, cost-effective, and suitable for routine analysis in pharmaceutical laboratories, ensuring the quality and potency of isoconazole-containing products.

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