FORMULATION AND EVALUATION OF FLOATING MICROSPHERE USING NATURAL POLYMER FOR THE TREATMENT OF ULCER
Akram Khan, Dr. Kapil Purohit
ABSTRACT
Gastric ulceration remains a significant health concern worldwide, necessitating the development of effective drug delivery systems for improved treatment outcomes. This study aimed to formulate and evaluate floating microspheres using a natural polymer for the treatment of gastric ulcers. The microspheres of Lansoprazole were prepared by the emulsion solvent evaporation method using sodium alginate as the natural polymer and calcium carbonate as a gas-generating agent. The formulated microspheres were characterized for their morphology, particle size, drug entrapment efficiency, in vitro drug release, and buoyancy properties. The developed microspheres exhibited a spherical morphology with uniform particle size distribution. The entrapment efficiency of the microspheres was found to be satisfactory, indicating efficient drug loading. In vitro drug release studies revealed sustained release behavior, with the majority of the drug released over an extended period, indicating their potential for prolonged gastric retention. Furthermore, the microspheres demonstrated excellent buoyancy properties, allowing them to remain in the gastric region for an extended period, thereby enhancing drug absorption and bioavailability. Overall, the developed floating microspheres using a natural polymer hold promise as a novel drug delivery system for the effective treatment of gastric ulcers, offering improved patient compliance and therapeutic outcomes.
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