FORMULATION, IN VITRO EVALUATION AND CHARACTERIZATION OF THE NANOPARTICLES SYSTEM OF DOCETAXEL
Vaishali Rajput, Dr. Rupesh Kumar Jain, Dr. Sunil K. Jain, Dr. Harshita Jain
ABSTRACT
The formulation, characterization, and evaluation of docetaxel nanoparticles were conducted to enhance its therapeutic efficacy. Nanoparticles were prepared using a solvent evaporation method, and their physicochemical properties were investigated. Microscopic observation revealed uniform and spherical nanoparticles. Evaluation parameters including particle size, polydispersity index, encapsulation efficiency, drug release, and zeta potential were determined for three different formulations. Formulation 3 exhibited the most promising characteristics with higher encapsulation efficiency, cumulative drug release, and more negative zeta potential compared to other formulations. These findings suggest that Formulation 3 holds potential for improved stability and controlled release of docetaxel. Further studies are needed to validate its therapeutic efficacy in vivo.
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