DESIGN AND CHARACTERIZATION OF PACLITAXEL LOADED NANOPARTICLES WITH PIPERINE
Surbhi Kurmi, Mr. Yashwant Singh Jat, Dr. Sunil K. Jain, Dr. Harshita Jain
ABSTRACT
Cancer treatment efficacy is often hampered by the limited solubility and systemic toxicity of chemotherapeutic agents, such as paclitaxel. Nanoparticle-based drug delivery systems have emerged as a promising strategy to overcome these challenges. This study focuses on the design and characterization of paclitaxel-loaded nanoparticles with the bioenhancer piperine, aiming to enhance the therapeutic potential of paclitaxel. The incorporation of piperine into paclitaxel-loaded nanoparticles aims to harness its bioenhancing effects, potentially improving the pharmacokinetics and therapeutic outcomes of paclitaxel. Piperine, derived from black pepper, has shown synergistic effects with paclitaxel in various cancer cell lines, making it an attractive candidate for combination therapy. In vitro drug release provide insights into the robustness of the formulation for clinical translation. This research endeavors to bridge the gap between conventional chemotherapy limitations and innovative nanotechnological solutions. By elucidating the intricate interplay between paclitaxel, piperine, and polymeric nanoparticles, this study seeks to contribute valuable insights that may pave the way for improved cancer treatment strategies with enhanced efficacy and reduced systemic toxicity.
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