PREPARATION AND OPTIMIZATION OF MUCOADHESIVE MICROSPHERE OF OMEPRAZOLE IN THE TREATMENT OF PEPTIC ULCER
Ravindra Balmiki, Shubham Patel, Chhaya Chadar, Reshu Jain, Harshna Vishwakarma, Yuvrajsingh Dangi, Asmita Gajbhiye and Shailendra Patil
ABSTRACT
Gastroesophageal reflux disease (GERD) refers to mucosal damage caused by the abnormal reflux of gastric contents into the oesophagus or beyond, into the oral cavity (including larynx) or lungs. A common condition seen in both, primary care and gastroenterology clinics, the prevalence of GERD (defined by at least weekly heartburn and/or acid regurgitation) has been reported to be 10%–20% in the Western world and <5% in Asia. In a prospective, multi-center study carried out by the Indian Society of Gastroenterology Task Force (n=3,224), 7.6% of Indian subjects were found to have significant GERD symptoms. Omeprazole is soluble in organic solvent such a ethanol and diamethylformamide (DMF). The solubility of omeprazole in ethanol is approximately 30mg\ml DMF and DMSO Microspheres mostly improve the bioavailability of the conventional drug. Microspheres are also called as micro particles. Microspheres are improving quality and particle distribution. Microspheres mostly improve the availability of drug. Microbeads & beads are used alternatively for microspheres.
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