DEVELOPMENT & COMPARISON OF PERCENT DRUG RELEASE FROM ASCORBIC ACID IMMEDIATE RELEASE TABLET USING VARIOUS POLYMER COATING IN DISSOLUTION MEDIA
Shubham Patel, Chhaya chadar, Reshu Jain, Ravindra Balmiki, Harshna Vishwakarma, Anamika Jain, Asmita Gajbhiye, Shailendra Patil
ABSTRACT
An aqueous granulation process was adopted to formulate ascorbic acid tablets. Wet granulations methods have been utilized for the formulations of ascorbic acid tablet. Ascorbic acid, MCC, stearic acid, talc was used for preparation. And coating ingredients HPMC, ethyl cellulose, acetate phthalate. Preformulations studies of ascorbic acid and drug excipient compatibility study was carried to optimize the formulations variables. Immediate release [IR layer] has been developed and evaluated for the various parameters. Thickness, hardness, friability, weight variation, in-vitro drug dissolution studies. The therapeutic efficacy of drug depends mainly types of behaviour of release of drug from dosage form the developed ascorbic acid tablets were taken on a model dosage form various coating are prepared to be applied on the dosage form and thus monitoring. The drug release in a controlled manner. The prepare of the study is to emerge the release behaviour in a controlled way and to compare various polymer and their grader on drug release pattern.
[Full Text Article]