EVALUATION IN VIVO ANTIDIABETIC ACTIVITY OF LEAVES EXTRACT OF CYMBOPOGON CITRATUS
Obed Ullah Khan, Mr. Manish Sahu, Dr. Jagdish Chandra Rathi
ABSTRACT
This study investigates the antidiabetic potential of the hydroalcoholic extract of Cymbopogon citratus leaves in streptozotocin (STZ)-induced diabetic rats. The hydroalcoholic extraction yielded 6.75%, and phytochemical screening revealed the presence of flavonoids, phenols, proteins, carbohydrates, and tannins. Total phenolic and flavonoid content were estimated to be 0.769 mg/100mg and 0.852 mg/100mg of dried extract, respectively. The study assessed the impact of the extract on body weight, blood glucose levels, and lipid profile. Rats treated with the extract (200 mg/kg and 300 mg/kg) exhibited significant improvements in body weight compared to the diabetic control group. Additionally, the extract demonstrated notable antidiabetic effects, as evidenced by a reduction in blood glucose levels and improvements in total cholesterol levels, especially at the dose of 300 mg/kg. These findings suggest that the hydroalcoholic extract of Cymbopogon citratus possesses antidiabetic properties, possibly attributed to its rich phytochemical composition. Further mechanistic studies are warranted to elucidate the underlying mechanisms of action.
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