CURRENT REVIEW ON NANOSPONGES FOR EFFECTIVE TREATMENT OF IBD
Sagar S. Kosalge, Pankaj M. Pimpalshende, Satish B. Kosalge, Naheed Waseem A. Sheikh
ABSTRACT
The chronic gastrointestinal tract condition known as inflammatory bowel disease (IBD) is marked by uncontrollably high levels of inflammation in response to dysbiosis of the gut microbiota and disruption of the intestinal epithelial barrier. The limited effectiveness of currently available small-molecule immunosuppressive drugs and anti-cytokine biologics is mostly attributable to the intricate inflammatory network associated with inflammatory bowel disease. Drug delivery devices called nanosponges are made of tiny sponges that have been mixed with medication. This technology has recently improved the treatment of numerous disorders that call for tailored delivery, such as IBD. This review will provide outline about IBD pertaining to its various aspects and further details of nanosponge from its characteristics, classification, preparation, evaluation, application, advantages and some notable works enlisting nanosponge mediated drug delivery.
[Full Text Article]