FORMULATION, DEVELOPMENT AND EVALUATION OF TRANSDERMAL PATCH OF LIPID-LOWERING DRUG
Sachin Brajvasi, Rahul Sharma, Dr. Jagdish Chandra Rathi
ABSTRACT
This research focused on the formulation, development, and evaluation of transdermal patches for the lipid-lowering drug Pitavastatin. Pitavastatin, a poorly water-soluble drug, poses challenges in achieving consistent bioavailability. The study aimed to enhance the solubility of Pitavastatin and provide sustained release through the application of solid dispersion techniques. Various formulations were prepared, incorporating polymers such as HPMC, Ethyl Cellulose, Eudragit RLPO, and Eudragit RSPO. The transdermal patches were evaluated for thickness, folding endurance, moisture content, moisture uptake, tensile strength, drug content, and in-vitro drug release. The optimized formulation (F4) exhibited promising characteristics with sustained release properties.
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