EXTRACTION, PHYTOCHEMICAL SCREENING AND FORMULATION OF HERBAL TABLETS FOR EFFECTIVE ANTI-DIABETIC EFFECT
Lokendra Singh Rathore, Dr. Pratyush Jain, Dr. Alok Pal Jain
ABSTRACT
This study aimed to extract bioactive compounds from Withania coagulans and formulate herbal tablets for the potential management of diabetes. Withania coagulans leaves were subjected to sequential extraction using various solvents, and the obtained extracts were screened for phytochemical constituents. The anti-diabetic potential was evaluated through in vitro assays. The most promising extract was incorporated into herbal tablet formulations using standard excipients. The extraction process yielded multiple fractions, with the ethanolic extract exhibiting the highest concentration of bioactive compounds, including alkaloids, flavonoids, and phenolics. In vitro assays demonstrated significant anti-diabetic activity, with notable effects on glucose uptake and inhibition of key enzymes involved in carbohydrate metabolism. Formulation of herbal tablets using the ethanolic extract, with optimized excipient ratios, resulted in tablets with acceptable physical characteristics, uniform drug content, and desirable disintegration properties. The extraction of bioactive compounds from Withania coagulans, particularly the ethanolic extract, revealed promising anti-diabetic potential. The successful formulation of herbal tablets provides a convenient and standardized dosage form for potential clinical applications. Further investigations, including preclinical and clinical studies, are warranted to validate the anti-diabetic efficacy and safety of these herbal tablets.
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