International Journal of Pharmaceutics & Drug Research

Amit Kumar Tyagi, Anshita Gupta, Dr. Vivek Gupta

ABSTRACT

When exposed to both infectious and noninfectious stimuli, the innate system's physiological homeostatic reaction is inflammation. One of the finest pharmacological classes for both preventing and treating pain is NSAIDs. But it has unfavorable effects on the kidney, cardiovascular system, and gastrointestinal tract are thought to be the main problems with these medications. Herbal medications function through an orchestrated strategy, in contrast to contemporary allopathic medications and also have zero side effects. Thus, this study will further assess the anti-inflammatory activity of fruits of S. lychnophora. The fruits of plant was collected, subjected to extraction & tested for qualitaiative, quantitative & anti-inflammatory studies. Results showed that the methnol & water extract obsrerved to have brown coloyur while the chloroform & ethyl acetate extract observed to have sticky brown & light brown colour. It can be seen that with the chloroform & ethyl acetate as solvent, the % yield was found to be 1.6 & 5.4% respectively. The methanolic extract had 7.5 % yield while the highest % yield was found with water that is 10.2%. Further phytochemical screening was performed to know the exact presence or absence of particular phytoconstituents. The maximum number of phytoconstyituents was present in methanolic extract. The ethyl acetate extract found to have total flavonoid content of 0.463mg/100mg. in case of methanolic extract the total phenol & flavonoid content was found to be 0.741 & 0.854 mg/ 100 mg respectively. Additionally the phenol & flavonoid content in aqueous extract was found to be 0.639 and 0.596 respectively. The anti-inflammatory activity of extract was performed by using Diclofenac sodium as standard. In this case the IC50 value for standard was observed to be 198.42 while for Sterculia lychnophora extract it was observed to be 331.94. From the results it can be stated that fruits of Sterculia lychnophora have appreciable anti -inflammatory activity.

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