EVALUATION OF CNS STIMULATION OF ASPARAGUS RECEMOSUS EXTRACT
Mohammad Zeeshan, Deepak Kumar Basedia, Vivek Singh Thakur, Bhushan Korde, B. K. Dubey
ABSTRACT
In order to treat psychological or neurological conditions, several cultural groups have utilized and altered natural resources for thousands of years. Treatment with plants and their contents can be thought of as targeting CNS functions as cognition, alertness, memory sedation. Thus, this study will aim at examining Asparagus racemosus extract for the treatment of CNS disorders. The plant material was collected, extracted, evaluated with qualitative and quantitative studies. The in vivo neuroprotective activity was checked by stair case test & elevated plus-maze test. The results showed that the percentage yield of Asparagus racemosus was found to be 8.62%. The phytochemical screening revealed the presence of flavonoid, saponin, phenolics, proteins, carbohydrate and diterpene. The total phenol & flavonoid content was estimated to be 0.251 mg/100mg and 0.563 mg/100mg respectively. At first the staircase test was performed. In rats treated with hydroalcoholic extract of Asparagus racemosus at 300 mg/kg concentration the No. of climbing in 3 min was observed to be 7.15±0.60 while the No. of rearing in 3 min was seen to be 5.00±0.55. Further, in Elevated plus maze test the No. of entry into elevated plus maze test was seen to be 6.66±1.20 in closed arm and 5.83±1.65 in open arm. The time spent in open arm was noticed to be 146.33±9.96. The obtained results were approximately close to rats treated with standard drug diazepam. These findings imply that the Asparagus racemosus hydroalcoholic extract has anxiolytic properties and may also have potential sedative and relaxing properties.
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