FORMULATION AND CHARACTERIZATION OF MOUTH DISSOLVING TABLET OF APREPITANT USING HYDROTROPIC SOLUBILIZATION TECHNIQUE
Jay Vishwakarma*, Komal Tikariya, Mr. Umesh K Atneriya, Arpit Gawshinde, Dr. Dharmendra Solanki
ABSTRACT
Mouth Dissolving Tablets (MDTs) use a novel idea that the pharmaceutical business has recently come to terms with. However, aparepitant has low solubility. As a result, this study will use the hydrotropic solubilization technique to formulate and characterize a aprepitant mouth dissolving tablet. The solubility of Aprepitant was first enhanced by choosing apprpopiate ratio of Drug to hydrotrope. The formulation & evaluation of tablet was performed by standard methods. Results showed that the solubility enhancement was found to be maximum 12.053 for 1:3 (Drug: Sodium acetate) The result of determination of drug content showed that about 99.85% drug got soluble with aid of hydrotropic agent. Further by using this ratio about nine formulations of mouth dissolving tablet was prepared. The loosen bulk density among the formulation varied from 0.336 to 0.358 gm/ml while the tapped density ranged from 0.442 to 0.463 gm/ml. The minimum & maximum cars index found was 22.511 and 25.328 %. The Hausner’s Ratio spanned from 1.291 to 1.339. The angle of repose ranged from 430 -450 . The post compression parameters revealed that % drug content was maximum in F7 formulation which is 99.87±0.27. The friability varied between 0.612±0.036 to 0.732±0.023. The hardness ranged between 3.2±0.2 to 3.4±0.3 kg/cm2 . The weight varied between 396±4 to 405±4%. The least disintegration time was reported with formulation F7 which is 38±2 seconds. The In-vitro drug release data for optimized formulation F7 revealed that about 99.12drug is released in 15 minutes. From the Regression analysis data it was observed that the R?2; value for zero order & first order was observed to be 0.799 & 0.999 respectively. Thus it is clear that the drug release occurs according to first order kinetics. Thus F7 was deemed to be the optimal formulation based on physicochemical attributes and can be further tested in clinical trials.
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