EVALUATION OF ANTI- ULCER PROPERTIES OF ARTABOTRYS HEXAPETALUS ROOT EXTRACT
Km Rupali Gupta*, Ms. Monika Parmar, Dr. Satkar Prasad
ABSTRACT
Peptic ulcers are one of the most common illnesses in humans, affecting over 10% of the global population. A number of synthetic medications, are available to treat peptic ulcers, however shoes adverse effects and drug interactions. Medicinal plants are a great source of medications with zero side effects. Artabotrys hexapetalus is one such unrecognized plant with various medicinal properties. Thus, this work aim at evaluation of anti- ulcer properties of Artabotrys hexapetalus root extract. The plant material was collected, extracted & subjected to in vitro & in vivo tests as per standard procedures. The results revealed that percentage yield in pet ether & ethanolic extract was estimated to be 2.5% & 7.6% respectively. The phytochemical screening of the hydroalcoholic extract of Artabotrys hexapetulus roots reveals the presence of several bioactive compounds, including alkaloids, glycosides, flavonoids, proteins, carbohydrates, and saponins. Total flavonoid & alkaloid content was found to be 0.965& 0.574 mg/ 100 mg of dried extract. In100 mg/kg and 200 mg/kg extract treated group the ulcer index was found to be 3.30±0.0 & 3.05±0.15 respectively while in control group the ulcer index was seen to be 6.5 ±0.15. Both doses of the extract (100 mg/kg and 200 mg/kg) show an increase in gastric pH of 3.85±0.15 & 4.15±0.15 respectively compared to the control group which is 2.65±0.10. The total acidity in 100 mg/kg & 200 mg/kg extract treated group was observed to be 55.75±0.15 & 43.15±0.20 mEq/lt respectively. While the free acidity in 100 mg/kg & 200 mg/kg extract treated group was estimated to be 41.15±0.10 & 36.50±0.20 mEq/lt respectively. The pepsin activity was found to be 3.10±0.25 & 2.65±0.15 Per ml/h for 100 mg/kg & 200 mg/kg extract treated group respectively. Thus results of all parameters indicate towards fact that the Artabotrys hexapetalus root extract have influential antiulcer activity.
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