International Journal of Pharmaceutics & Drug Research

Anurag*, Dr. Satkar Prasad

ABSTRACT

Acne is widespread during adolescence, affecting approximately 80-90% of teenagers. Allopathic medications, on the other hand, might have a variety of negative effects. Herbal remedies for acne therapy have been used since ancient times and include diverse herbal extracts, oils, and ayurvedic formulations. Citrullus colocynthis medical applications have been described in indigenous systems of medicine from numerous regions. Reviewing this plant usefulness this study deals with evaluation of in-vivo anti-acne activity of medicinal plant Citrullus colocynthis. Plant part was gathered, extracted with appropriate solvent investigated for qualitative as well as quantitative analysis. The anti -acne activity of extract was checked in both in vitro & in vivo systems. Resulta showed that the % Yield of pet. Ether and hydroalcoholic extract of Citrullus colocynthis were found to be 3.2% and 8.7% respectively. Citrullus colocynthis is a rich source of different secondary metabolites like alkaloids, flavonoids, carbohydrates, saponins and diterpenes. Total flavonoid & alkaloid content of hydroalcoholic extract of Citrullus colocynthis was found to be 1.02 mg/ 100 & 0.56 mg/ 100 respectively. The zone of inhibition for Citrullus colocynthis extract was observed to be 14±0.57mm, 9±0.94mm & 8±0.5mm at concentration of 100 mg/ml 50 mg/ml & 25mg/ml respectively. The ear thickness was found to be 0.09 at 10th day in clindamycin treated group. In case of Citrullus colocynthis extract 100mg/kg & 200mg/kg the ear thickness at 10 th day was observed to be 0.22 & 0.18. Thus, the extract at this dose demonstrated a rapid and sustained reduction in inflammation, highlighting its strong anti-acne potential.

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