OPTIMIZATION AND EVALUATION OF CLARITHROMYCIN FLOATING TABLET USING DIFFERENT NOVEL POLYMERS
Ashish Mohan, Amit Sahu, Dr. Kavita R. Loksh, Dr. Sarita Karole
ABSTRACT
H. pylori is a substantial contributor to peptic ulcers Getting the antibiotic into the stomach right away is one way to increase the effectiveness of the H. pylori eradication process. The creation of hydrodynamically balanced devices or floating drug delivery systems can accomplish this. This study deals with optimization and evaluation of clarithromycin floating tablet using different novel polymers. The formulation & evaluation of floating tablet was performed according to standard protocol. Results showed that, the formulation AF3 was specifically analysed to study the effect of hardness on floating lag time, revealing that increasing hardness led to an increase in floating lag time due to reduced porosity. Regarding in-vitro dissolution, batch AF3 containing HPMC K15M demonstrated a favourable drug release rate compared to the other batches. Clarithro ER indicated that the optimized formulation AF3 offered superior control over the release rate. Consequently, it was concluded that formulation AF3 containing HPMC K15M displayed a better-controlled drug release rate compared to other polymers.
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