IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF CLOBAZAM ORODISPERSIBLE TABLETS USING NATURAL POLYMERS

Aman Kumar, Dr. Pankaj Tiwari, Dr. Kavita R. Loksh, Dr. Sarita Karole

ABSTRACT

Epilepsy affects over 50 million people worldwide, 90% of whom are from developing nations. Design of new dosage forms has taken on a lot of significance as a means of enhancing compliance and making administration more convenient. The purpose of this effort is to build an orodispersible clobazam tablet which will begin working within a few minutes. The formulation evaluation of tablet was done according to standard methods. Results of pre compression parameters showed that the loose bulk density was found to be ranged from 0.325 gm/ml to 0.348 gm/ml while the tapped density ranged from 0.435 gm/ml to 0.456 gm/ml. The carr’s index varied from 22.838 to 25.885. The Hausner’s Ratio spanned from 1.296 to 1.349. The angle of repose found to be in range between 430 to 450 . Hardness ranged within 3.1 to 3.4 kg/cm2 while the friability varied from 0.568 to 0.745. The weight variation extends from 98 to 105. The thickness of tablet ranged from 1.36 to 1.63 while the % drug content seen to in between 97.74 to 98.85%. Beyond that the least disintegration time was observed for formulation F7 which is 36±3 seconds. The in vitro drug release data suggested that in just 15 minutes about 98.85% drug is released. From the obtained R² value it is clear that drug relase by formulation F7 follows zero order kinetics. From the results it is clear that it is clear that the drug-loaded oral dispersible tablet was reliable and exhibits an improved drug release profile.

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