IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

FORMULATION AND CHARACTERIZATION OF DEXLANSOPRAZOLE FAST DISSOLVING ORAL WAFERS

Akshay Kumar Meena, Dr. Pankaj Tiwari, Dr. Kavita R. Loksh, Dr. Sarita Karole

ABSTRACT

GERD a chronic gastrointestinal illness with a prevalence of 20%, often diagnosed digestive illnesses. As an alternative to capsules, tablets, and syrups for elderly and young patients who have difficulty swallowing, rapid disintegrating drug delivery systems were created in the late 1970s. Fast dissolving wafers which are more convenient and simple to use than other dosage forms like orally disintegrating tablets. Therefore, the creation of fast-dissolving oral wafer formulations will be aim of this project. The formulation & evaluation of wafer was performed as per protocol. Results showed that the weight variation among the eight formulations ranged from 122±2mg to 139±5mg. The thickness also varied between 0.23±0.02 to 0.28±0.03 mm. The tensile strength spans from 1.68±0.15 MPa for F8 formulation to maximum of 3.25±0.25 MPa for F1 formulation. The folding endurance was found to be highest for F7 formulation which is 185±5. Further, the least disintegration time observed was 31±3 which is also the attribute of F7 formulation. Additionally the drug content was found to be maximum for F7 again with the value of 99.45±0.47 %. The cumulative % drug release was observed to be 99.92 % in 10 minutes for F7. The stability studies of optimized formulation F7 indicated that formulation remained stable for 3 months. It can be concluded that fast-releasing sublingual wafers of Dexlansaprazole is developed for the rapid and effective drug delivery with increased bioavailability.

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