FORMULATION AND EVALUATION OF AQUASOMES FOR TRANSDERMAL DRUG DELIVERY OF MUPIROCIN
Sangeeta Dange, Mr. Satyawan Singh Dangi, Dr. Satkar Prasad
ABSTRACT
Transdermal drug delivery represents a promising approach for improving the efficacy and patient compliance of topical antibiotic treatments. In this study, we aimed to formulate and evaluate Aquasomes as a carrier system for the transdermal delivery of Mupirocin, a potent antibiotic widely used in dermatological applications. Aquasomes, nanosized vesicular structures characterized by their core-shell composition, were prepared with the objective of enhancing drug permeation through the skin. The formulation process involved the encapsulation of Mupirocin within Aquasomes, followed by a comprehensive assessment of their physicochemical attributes, in vitro drug release kinetics, skin permeation capabilities, and stability under various storage conditions. The study employed a range of analytical techniques to evaluate the performance of Aquasomes as a drug delivery system. The results demonstrated successful formulation of Aquasomes with high entrapment efficiency, indicating efficient encapsulation of Mupirocin. In vitro drug release studies revealed controlled and sustained drug release from Aquasomes, suggesting their potential for extended therapeutic action. Skin permeation studies exhibited enhanced drug permeation through the skin, highlighting the capacity of Aquasomes to improve transdermal drug delivery. Furthermore, stability assessments indicated that Aquasomes maintained their physicochemical properties under different storage conditions. The findings suggest that Aquasomes hold the potential to enhance the therapeutic efficacy of Mupirocin in the treatment of skin infections while offering a platform for the development of patient-friendly topical formulations. In conclusion, the utilization of Aquasomes in transdermal drug delivery represents an innovative strategy with the potential to improve therapeutic outcomes and patient adherence in the management of skin infections using Mupirocin.
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