FORMULATION AND EVALUATION OF ELASTIC LIPOSOMES OF STREPTOMYCIN SULFATE
Shashikant Kumar, Samreen Ali, Dr. Ashish Manigauha
ABSTRACT
In the past few decades, skin conditions have become more common, placing a heavy load on healthcare systems all around the world. The creation of novel medications has traditionally been a standard procedure in the search for safe and effective treatments. Thus, this study aims at formulation and evaluation of Elastic Liposomes of Streptomycin sulfate. The formulation & evaluation of liposomal gel was performed according to standard protocol. Results showed that. At first five formulations of liposomes were created. The vesicle size was found to be ranged from 169.98±2.85 nm in case of F5 to 232.26±3.32nm in case of F3. While the entrapment efficiency ranged from 64.58±0.23 % for F2 to maximum of 74.65±0.14 % in F5. The zeta potential was found to be - 25.4 mv for the same F5 formulation. Further by using F5 formulation the three different formulation of liposomal gel were made. The pH of gel LG 2 was also close to skin pH which is 6.81. The spreadibility for LG2 was found to be 10.26. The in vitro drug release study indicated in 10 hours the % cummulative drug release was found to be 98.45 %. The high R² values of 0.993 for Korsmeyer-Peppas equation suggest that these models provide a good description of the drug release behavior of the elastic liposome gel formulation. Stability studies for optimized formulations were carried out at 4.0 ? 0.5?C and 28 ± 0.5ºC for a period of four weeks. There was no significant variation found in physical appearance, average particle size and % drug content of the elastic liposomes gel. Thus from the results it can be interpreted that liposomal gel of Streptomycin sulfate could be used for treatment of bacterial skin infection.
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