International Journal of Pharmaceutics & Drug Research

Vikas Chauhan, Kehar Singh Dhaker, Manju Prajapati

ABSTRACT

Nanoparticles have an enormous impact on society. Selenium nanoparticles are used in various oxidative stresses. Selenium nanoparticles (SeNPs) have attracted lots of attention recently owing to their excellent bioavailability and low toxicity. However, the stability of SeNPs needs to be improved. The 5-nitroimidazole drug metronidazole has remained the drug of choice in the treatment of anaerobic infections, parasitic as well as bacterial, ever since its development in 1959. In contrast to most other antimicrobials, it has a pleiotropic mode of action and reacts with a large number of molecules. The objective of the present study was to formulate and evaluate selenium nanoparticles of metronidazole for oral delivery of bioactives. The synthesized SeNPs were characterized using particle size, zeta potential, entrapment efficiency, scanning electron microscopic (SEM), In vitro drug release. There was no interaction between the medication and the excipients in FT-IR experiments. The improved formulation's percent EE, particle size, and zeta potential were found to be 98.23%, 149.1 nm and -3.9 mV respectively. F4 was shown to be the most promising formulation among all created formulations in this investigation. Scanning electron micrograph of the prepared nanoparticle at 8.21 kx magnification showed that the nanoparticle were smooth surface morphology and spherical shape. Among all, the formulation F4 was found to be best formulation which releases 97.92% of the drug within 24hr. The data obtained from In-vitro release were fitted into the various kinetic models such as Zero Order, Higuchi, First Order and Korsmeyer–Peppas Model in order to determine the mechanism of drug release. When the regression coefficient values compared, it was observed that ‘r’ values of formulation F4 was maximum i.e 0.955 hence indicating drug release from formulations was found to follow Higuchi drug release kinetics. The current project also aims to improve the formulation's pharmacological acceptability.

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