International Journal of Pharmaceutics & Drug Research

Mohit*, Eisha Ganju, Bhaskar Kumar Gupta

ABSTRACT

Fungal infections are opportunistic, which means they infect persons with highly damaged immune systems. The effectiveness of topical antifungal treatment is dependent on medication penetration through the targeted tissue. NLCs (nanostructured lipid carriers) are innovative pharmaceutical formulations. Also, gel combined with lipid nanoparticles was used to reduce skin irritation and to transfer medications into deeper layers of skin. This study deals with formulation, development and evaluation of nano structured lipid careers incorporated gel for effective fungal treatment (isoconazole). The formulation & evaluation of NLC gel was done according to standard methods available. The particle size ranged from 215.25 to 278.85. The drug content was found to be maximum in F14 formulation which is 99.45 %. The entrapment efficiency of F14 was noted to be 83.32. The % Cumulative Drug Release for F14 was estimated to be 99.12 % in 12 hours. Further by using F14 formulation the gel was made. The viscosity of gels ranged from 3110±7 to 3542±10cps while pH spanned between 6.81±0.02 to 6.98±0.01. The percentage of drug was observed to be maximum in G-2 which is 99.12±0.15. The extrudability extends from 159±3 to 175±5g. While the spreadibility was seen to range from 7.45±0.13 to 10.21±0.12. The in vitro drug release study of optimized gel formulation G-2 suggested that about 98.74% drug release is achieved in 12 hours. The mean particle size & zeta potential was observed to be 214.45nm & -36.48mV respectively. The Cumulative % Drug Release for optimized formulation of gel G2 estimated to be 98.74% in 12 hours. The R?2; value 0.955 indicated that it follows first order kinetics. It can be concluded that the isoconazole-loaded NLCs gel have a prolonged release profile and have the potential to treat fungal topical infections.

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