International Journal of Pharmaceutics & Drug Research

Saurabh Balpande*, Dr. Shailendra Kumar Lariya, Dr. Shailendra Bindaiya

ABSTRACT

Skin illnesses are frequent and have a significant impact on the quality of life of sufferers. The use of long-term antibiotics for treatment causes organisms to acquire drug resistance. A wide range of medicinal plants have been identified as valuable sources of natural antibacterial substances as an option that may be effective in the treatment of these troublesome bacterial infections. Thus this study deals with formulation & evaluation of polyherbal gel made of extract of Pistacia lentiscus, Alhagi camelorum and Litsea glutinosa. The plant materials were collected & subjected to extraction. Further qualitative & quantitative studies were also performed. The formulation & evaluation of gel was performed according to standard protocol. Results revealed that hydroalcoholic extract of Pistacia lentiscus contains alkaloid, flavonoids, diterpenes & tannin. The Alhagi camelorum found to have traces of alkaloid, flavonoid, phenol, protein & diterpene. In case of Listea glutinosa only glycosides, phenol, proteins & tannin were found to be present. The total flavonoid content in Pistacia lentiscus was estimated to be 0.964 mg/ 100 mg. In case of Alhagi camelorum total phenol & flavonoid content was quantified as 1.925 & 1.544 mg/100mg respectively. In case of Litsea glutinosa in total 1.600 mg/100mg of phenol was noted. The morphological characteristics shown that the formulated gel is devoid of clogging with good Homogeneity & smooth texture with light brown colour. The washability of all formulations was good while the Extrudability was average for some & good for few formulations. The maximum spreadability ranged from24.24±2 to 32.32±2 gcm/sec. The pH of formulations ranged from 4.76±0.21 to 7.21±0.12. The most viscous formulation was noticed to be PHG3 with viscocity of 3241±32 cps. Further the phenol content & flavonoid content in PHG4 was found to be 82.6±0.4%. & 85.3±0.3 % The polyherbal gel with concentration of 0.5mg/ml, 0.25 mg/ml & 0.125mg/ml estimated to have zone of inhibition of 16±0mm, 15±0.57mm & 12±0.5mm against E.coli respectively. While for Staphylococcus aureus at same concentration 14±0.47mm, 10±0.5mm & 9±0.74mm respectively. So, it is clear that Polyherbal gel is slightly more potent against E.coli in contrast to S. aureus.

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