IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

FORMULATION AND CHARACTERIZATION OF GASTRORETENTIVE NANOSPONGES OF DEXLANSOPRAZOLE

Roshan Rewatkar*, Dr. Shailendra Kumar Lariya, Dr. Shailendra Bindaiya

ABSTRACT

Gastro-oesophageal reflux disease is a common disorder characterised by the reflux of stomach contents into the oesophagus, resulting in unpleasant symptoms and problems. The prevalence of this illness is rising, and this rise has been connected to population ageing and the global obesity crisis. Numerous efforts have been made over the last three decades to develop a dose form that can be kept in the upper part of the GIT which will increase the bioavailibilty of anti-ulcer medication. Thus this study aims at formulation and characterization of gastroretentive nanosponges of dexlansoprazole. The Nnosponges were prepared by emulsion solvent diffusion technique & evaluated for various parameters. Results revealed that the maximum percentage yield was noticed to be 80.32±0.22 in F3 formulation. Further, the highest entrapment efficiency was observed in F3 formulation which is 74.45±0.45%. The results of measurement of mean particle size & zeta potential of optimized formulation F3 nanosponges were found 136.65 nm & -35.65 mV respectively. Also, it was observed that upto 97.74% drug release was achieved in nansponge within 12 hours. The plain drug release was noticed to be 48.87% in 2 hours. Thus this results showed that nanosponge have sustained release drug delivery over conventional formualtions. From regression analysis data it was clear that nanosponge follow first order kinetics with R² value of 0.982. The stability study of optimized formulation of nanosponges F3 was performed for duration of 3 months. The ?for at 4.0 ±0. 2°C was observed to be 72.14±0.36 with normal physical appearance within 3 months. Thus it can be interpreted that formulated nanosponges of dexlansoprazole possess all ideal parameters & can be used for treatment of GERD.

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