FORMULATION DEVELOPMENT AND EVALUATION OF COLON TARGETING MICROSPHERE
Yogendra Sikarwar, Dr. Kratika Daniel, Dr. Sudha Vengrulekar, Dr. Sachin K. Jain
ABSTRACT
Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amebiosis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs Thus selective delivery of drugs to the colon could not only lower the required dose but also reduce the systemic side effects caused by high doses. Microspheres are defined as “Monolithic sphere or therapeutic agent distributed throughout the matrix either as a molecular dispersion of particles”. The aim of this study is to prepare microsphere loaded with Rifaximin for colon targeting. The result showed that the percentage yield of different formulation was in range of 69.85±0.26 – 79.85±0.25%. The maximum percentage yield and entrapment efficiency was found formulation F3. Results of zeta potential of optimized formulation F4 microspheres were found to be -30.50 mV respectively. The average particle size of microspheres was found 185.65, 186.32 and 182.25nm after 1, 2 and 3 month of storage at 4.0 ±0. 2°C while at 25-28±2°C the average vesicle size was found 196.25, 215.65 and 285.45 nm after 1, 2 and 3 month of storage. ? in microspheres formulation was 73.32, 72.12 and 70.15?ter 1, 2 and 3 month of storage at 25-28±2°C while there were no significant changes in ?and physical appearance in microspheres formulation was observed after 3 month of storage at 4ºC.Thus, from the above results itt can be concluded that the prepared microsphere have all ideal characteristics parameters and can be used for colon targeted delivery.
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