FORMULATION AND EVALUATION OF MELOXICAM LOADED AQUASOMES FOR ENHANCED TOPICAL DRUG DELIVERY
Nizamuddin Chaudhary*, Abhishek Kumar Sen, Dr. Kavita R. Loksh, Dr. Sarita Karole
ABSTRACT
Traditionally topical drug delivery systems are used to relieve various skin conditions like pain, swelling & inflammation. The most difficult aspect of TDDS is overcoming the stratum corneum barrier effect, delivering the drug to the skin tissue, and passing through the cellular and vascular tissue to reach the target area. The issue is that just a little amount of medication can be administered through skin tissue. This issue can be addressed by aquasome. Aquasomes (AQ) are self-assembling nanostructures with a spherical hydroxyapatite core and a carbohydrate layer on top that are used to distribute bioactive compounds. Thus this study aims at formulation & evaluation of aquasome of Meloxicam for reducing pain & inflammation. The preparation & evaluation of aquasome was done according to standard protocol. Six different formulations were created & tested for various parameters. From the results, it was observed that the vesicle sizes vary among the different formulations. F3 has the smallest vesicle size 115.32 nm, while F6 has the largest vesicle size 155.65 nm. The formulations have negative surface charges, ranging from -29.98 to -39.98 mv. The F3 formulation shows the highest entrapment efficiency 73.32% & F1 has the lowest entrapment efficiency 62.25%. The In vitro drug release study of optimized formulation F3 revealed that about 98.85% drug is released in 12 hrs. The R2 value for Higuchi kinetics in formulation F3 was 0.998 suggests an excellent fit to this model. Stability study data revealed that the optimized formulation F 3 can remain stable after 3 month of storage at 4ºC.
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