IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

FORMULATION AND CHARACTERIZATION OF FAST DISSOLVING ORAL WAFERS CHLORTHALIDONE

Manish Patel*, Lokendar Singh, Rakesh Solanki, Rupesh Soni

ABSTRACT

Hypertension is a highly hazardous disease; it can come at any time in elderly individuals, thus medications are available at all times and can be administered by patients in a very simple manner. To address these issues, formulators have made significant investments in the development of innovative drug delivery systems (NDDS). Fast dissolving wafers are one such method. Being a very useful drug for decreasing hypertension, this work aims at Formulation and Characterization of fast dissolving oral wafers of Chlorthalidone. The formulation & evaluation of oral wafer was performed according to standard protocol. In total nine formulations were created and all were found to be translucent. The thickness found to be ranged from 78±3 µm to 93±4 µm while the weights of formulations found to be varied from 105±5 mg to 117±8mg. The folding endurance was observed to be maximum for F7 which is 195±2 times. The pH ranges of formulations varied from minimum 6.72±0.15 to 6.95±0.14. The % moisture content varied from 2.3±0.4 to 2.9±0.5. The drug content was found to be maximum for F7 which is 99.85±0.25% also, the disintegrating time was observed to be 16±2 second. The in-vitro release study of optimized formulation F7 was observed to be 98.85 at 300 seconds. Minor difference was found between evaluated parameters before and after ageing/storage and all was in acceptable limits. Therefore formulation remains stable for sufficient time. Thus, it can be concluded that formulation of F7 have all ideal parameters & can be further implicated for clinical trials.

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