International Journal of Pharmaceutics & Drug Research

Mahendra Dwivedi *, Dr. Satkar Prasad

ABSTRACT

Inflammation is a healing process triggered by the tissue in reaction to an injury caused by infections, irritants, or cell damage. Antiinflammatory medications utilized routinely have much negative effects.Considering the huge medicinal properties of P. Santilanus plant this work is dedicated to elucidate In Vivo anti-inflammatory effect of Pterocarpus santalinus. The stem of the plant was collected & subjected to hydroalcoholic extraction. Further qualitative & quantitative estimation of phytochemical was performed by standard procedures. The in vivo anti-inflammatory activity was checked in wistar rats with caragreen induced paw edema. Indomethacin was used as standard drug. Results showed that plant contains phytochemicals like glycoside, flavonoid, saponin, phenolics, protein, carbohydrate, protein. The total phenol & flavonoid content was found to be 0.387 mg/100mg & 0.756 mg/100mg respectively. The groups treated with 100 & 200mg/kg have reduced paw edema of 2.8 ±0.05&1.3 ± 0.04in fourth hour respectively. While using indomethacin as standard drug it was seen that the paw volume was reduced to 0.90±0.05. So, the values indicate that the anti-inflammatory activity of P. santilanus is comparable to that of standard drug & reflects its activity in dose dependent manner.

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