PREPARATION AND EVALUATION OF ETHOSOMES OF MEDICINAL PLANT TRIDAX PROCUMBENS EXTRACT
Sujit Trimbak Karpe*, Shashikant Devidas Modekar, Kaustubh Sachin Kamble, Mahesh Shirish Nagode, Darshana Devidas Waghmode
ABSTRACT
Since the beginning of time, medicinal herbs have been utilized in India to promote the health of both people and animals. However, there are drawbacks to their use, including decreased bioavailability, activity loss upon exposure to light and air, and worse patient compliance due to bad taste. The majority of issues related to the use of medicinal plants are addressed by the innovative drug delivery technology like ethosome. Thus this study deals with preparation and evaluation of ethosomes of medicinal plant Tridax procumbens. The plant material was collected & subjected to extraction by maceration method using aqueous solvent. Further the qualitative test & formulation, evaluation of herbal ethosomes was performed by standard methods. Results showed that plant contain alkaloids, glycosides, flavonoids, saponins, tannins and anthracyanin. Further, the prepared ethosomes noticed to be spherical in shape, uniform in size with smooth surface. The particle size of all four formulations was found within the range 1025.6 – 1916.7 nm. . Small vesicle size is formed with the F2 formulation having minimum concentration of lecithin i.e., 0.5%. In comparison with other formulations, TPF2 showed the less polydispersity index which indicated the homogenous population of ethosomes. So, among all four formulations TPF2 has better homogeneity. Zeta potential of the TPF formulations was found in the range -36.0 to -11.0 mV. The formulation TPF2 is more stable than others as it has the highest homogeneity and zeta potential. The ?max was found to be 243nm. Formulation TPF2 was found best one as it has the highest entrapment efficiency i.e. 94.92%. The entire study makes it abundantly evident that ethosomes made with Tridax procumbent extract exhibits a synergistic impact, & can produce outstanding results in the treatment skin infections
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