IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF MUCOADHESIVE TABLETS OF LERCANIDIPINE

Vikas Singh*, Mrs. Reena Shende, Dr. Satkar Prasad

ABSTRACT

Arterial hypertension is the most common cardiovascular disease today & is linked to rising obesity rates and sedentary lifestyles. The traditional dosage form of antihypertensive medicines causes a lot of trouble and changes in therapy, as well as various Because mucoadhesive drug delivery provides rapid absorption and good bioavailability negative effects this study aims at development & evaluation of mucoadhesive buccal tablets of Lercanidipine. The formulation & evaluation of tablets was carried out as per standard protocol. Total six formulations were made by modulating the concentration of ingredients. Results revealed that the bulk density for six formulations was found to be ranged from 0.374 to 0.385. Tapped density varied from 0.473 to 0.492. Further the Compressibility index was seen to ranged from 21.75 to 23.00. The Hausner ratio was observed to be ranged from 1.278 to 1.299. The drug content was found to be maximum in F3 which is 99.45±0.20%. The thickness & hardness for F3 was noticed to be 3.11±0.04mm & 5.4±0.4 kg/cm2. While the weight variation & friability was estimated to be 246±7 mg & 0.658±0.013%. The maximum swelling in F3 formulation at 12 hours was noticed to be 103.25%. The % Cumulative Drug Release for F3 at 12 hrs was observed to be 99.45. When the regression coefficient values of were compared, it was observed that ‘r2’ values of First Order was maximum i.e. 0.978 hence indicating drug release from formulations was found to follow First Order kinetics. Thus, it can concluded that F3 formulation is have all ideal parameters and effective for speedy action, and appears to offer an alternative to the traditional table.

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