FORMULATION AND EVALUATION OF FELBINAC LOADED TRANSFEROSOMES GEL FOR ANTI-INFLAMMATORY EFFECT
Namrata Raj*, Mr. Brajesh Kumar Pathak, Dr. Ashish Manigauha
ABSTRACT
One of the main causes of heart disease is hypertension, and in recent years, both the age-adjusted mortality rates for these conditions have been rising. In order to improve the therapeutic efficacy of the treatment and lessen its negative effects, transdermal patches distribute the drug via the skin in a controlled and predetermined manner. Thus, this study aims at formulation & evaluation of transdermal patch of Nitrendipine to treat hypertension. The formulation of patch was done by standard procedure & its evaluation was performed for various parameters. Results revealed that For F3 formulation the maximum thickness was found to be 92±4 ?m & folding endurance was noticed as 195±4. The % moisture content & uptake for F3 was found to be 5.11±0.28 % and 2.15±0.11% respectively. Tensile strength for F3 was observed as 0.68±0.04 kg/cm2. The % drug content for F3 was also highest which is 99.12±0.25. The In vitro % permeation profile observed maximum for F5 which is 99.85 for 12hr. In-vitro drug release data for optimized formulation F3 revealed that Nitrendipine transdermal patches follow zero order kinetics which is evident from R2 value 0.957. Thus, from the results it can be concluded that the transdermal patch is both efficient and the preferred approach for treating hypertension.
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