FORMULATION AND EVALUATION OF FELBINAC LOADED TRANSFEROSOMES GEL FOR ANTI-INFLAMMATORY EFFECT
Anukool Shukla*, Mr. Muraree Lal, Dr. Avinash Krishnrao Kondalkar
ABSTRACT
Inflammation is a process that occurs as a result of tissue damage, generating venule dilatation, increased vascular permeability, and infiltration of histamine, cytokines, and other inflammatory components. The strong medications frequently have off-target effects, which significantly reduces patient compliance. Furthermore, traditional nonsteroidal anti-inflammatory drugs face numerous formulation problems. The goal of this study is to development & evaluation of transferosomal gel of Felbinac for treating inflammation. The falbinac was first procured. The optimization of transferosome was performed for various parameters. Further transferosomal gel was prepared by standard methods. Results revealed that formulation F-12 have all ideal characteristics. The size & zeta potential for F-12 was noted to be 125.45nm & -38.12 mv respectively. The % Entrapment efficiency for the same was found to be 75.65%. The optimized transferososmal gel has Extrudability & Spreadability of 178±4 gm & 13.36±0.15 g.cm/sec respectively. The gel viscosity was estimated to be 3256±15 cps. In vitro drug release study of prepared gel formulation revealed that 96.65% of drug was released in 12 hr. The release kinetics data of optimized transferosomal gel suggested that it follows Korsmeyer model which is evident from R2 value of 0.990. Stability study data revealed that the gel is stable for 3 months at 4.0 ±0. 2°C with average particle size of 236.45 nm & % Entrapment efficiency of 70.12. So, it can be concluded that the combined action of felbinac and transferosome for topical administration can be used in the treatment of inflammation.
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