DEVELOPMENT AND EVALUATION OF FLURBIPROFEN LOADED TRANSFEROSOME TO IMPROVE TRANSDERMAL DELIVERY
KM Ritika Upadhyay*, Mrs. Reena Shende, Dr. Satkar Prasad
ABSTRACT
Osteoarthritis is a degenerative joint disease that can affect a variety of joint tissues. It is the most common type of arthritis, affecting about 32.5 million adults. Traditional drug delivery systems include benefits as well as drawbacks such as low solubility and permeability, poor bioavailability, degradation by GI enzymes, first pass metabolism, dietary interactions, high dose required, and related drug toxicity. Thus, this study aims to develop transferosomal gel of Flurbiprofen for treating arthritis. The formulation and evaluation of formulated gel was performed as per standard protocol. Results showed that the F-12 formulation has the smallest vesicle size of 165.58% and the highest entrapment effectiveness of 73.49%. F12's zeta potential was found to be -38.85. Furthermore, transferosomal gel evaluation revealed that the optimised gel OTGF1 had Extrudability (g) and Spreadability (g.cm/sec) of 185±2.5 g and 11.15±1.5 g.cm/sec, respectively. The gel's viscosity was measured to be 32151±8 cps. The transferosomal gel % assay was estimated to be 98.15±0.32%. At 12 hours, the % Cumulative Drug Release was found to be 92.23. The r 2 value from release Kinetics of optimized gel of transferosomal gel was observed to be 0.990 and follows Higuchi model. So, it can be concluded that Transfersomal gel was profitably developed to improve the stability of drug-carrying vesicles and to make it easier to apply to the skin.
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