FORMULATION AND DEVELOPMENT OF EMULGEL FOR TOPICAL DELIVERY OF ISOCONAZOLE TO TREAT FUNGAL DISEASES
Ketan Pandey*, Mrs. Reena Shende, Dr. Satkar Prasad
ABSTRACT
Fungal illnesses require more attention than ever before, considering the growing population of immunocompromised people who are more vulnerable to these diseases. Topical drug delivery systems have been used for centuries to treat local skin ailments. One such delivery system is emulgel. Emulgel, is being employed to successfully include a hydrophobic medicinal moiety while enjoying the distinctive properties of gels. Also, the emulgels are emollient, nonstaining, high shelf life, bio-friendly, translucent, and attractive appearance. Thus, this study aims at formulation & evaluation of emulgel of Isoconazole for treating fungal disease. The preparation & evaluation of emulgel was performed as per standard protocol. Results showed that all the six formulation had good washability, absence of clogging & good homogeneity. The colour of all the formulation was white cream. The Extrudability ranged from excellent to average. The spread ability extent was observed from minimum of 10.32 for F3 & maximum of 13.36 for F4. The maximum viscosity was observed for F4 which was 3265±14 cps. While the minimum viscosity was noted for F3 which was 3115±11 cps. The pH of all the formulation were close to the pH of skin hence acceptable. Further % drug content studies indicated that formulation F3 have maximum drug content of 99.12±0.25 %. The % Cumulative drug release of formulation F1-F6 data, point towards fact that, within 4 hours the maximum drug release was observed in case of F3 formulation. Also, The In vitro drug release data for optimized formulation F3 proved that this is most suitable formulation which can be used to treat fungal infection. Thus, it can be summarized that Isoconazole emulgel, being hydrophobic in nature and can be considered as a potential topical alternative for the treatment of skin infections and attaining controlled release with higher bioavailability and for drug delivery.
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