International Journal of Pharmaceutics & Drug Research

Vaishali Pandey*, Dr. Shailendra Kumar Lariya, Dr. Shailendra Bindaiya, Dr. Sandesh Asati

ABSTRACT

Up to 10% of people worldwide are affected by the chronic condition known as peptic ulcer. There are many chemical treatments for peptic ulcers, but some of them have unfavourable side effects. Herbal remedies are thought to be safe for the treatment of ulcers. One such medicinal plant is, Plumbago zeylanica and has been accepted in numerous traditional medical systems for the treatment of a variety of human ailments. Thus, goal of this work is formulation and evaluation of phytosome of Plumbago zeylanica. For that the plant material was collected and subjected to extraction by hydroalcoholic solvent. The qualitative, quantitative studies as well as preparation and evaluation of phytosome were performed by standard methods. Results showed that plant contain alkaloid, glycoside, flavonoid, phenol, protein, carbohydrate, saponin and tannin. Total phenol and flavonoid content was observed to be 1.52 mg/100mg and 1.69 mg/100mg. The In-vitro drug release data for optimized formulation F10 showed that at 12 hrs the drug release was found to be 98.98%. When the regression coefficient values of were compared, it was observed that ‘r2’ values of Higuchi was found maximum i.e. 0.977 hence indicating drug release from formulations was found to follow Higuchi order release kinetics. Results of stability studies clearly indicates that optimized batches of phytosomes were stable over the chosen temperature and humidity conditions up to 3 months as were found no significant variation in physical appearance and % drug content. From results it can be summarized that phytosomes of hydroalcoholic extract of Plumbago zeylanica roots can be used to treat ulcer.

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