IJPDR

International Journal of Pharmaceutics & Drug Research

ISSN No. 2347-6346

Abstract

PHYTOCHEMICAL EVALUATION AND IN VIVO HEPATOPROTECTIVE ACTIVITY OF STERCULIA LYCHNOPHORA (FRUIT)

Kaushtubh Shrivastava*, Mrs. Seema Sahu, Mr. Himanshu Bhusan Sahoo, Dr. Om Prakash Agrawal

ABSTRACT

The ninth most prevalent cause of mortality in both developed and developing nations, cirrhosis is the most drug-stimulated liver injury, placing liver disease among the world's major health concerns. Since ancient times, medicinal herbs have been utilized to cure liver disorders as it is devoid of any side effects. This study deals with phytochemical evaluation and in vivo hepatoprotective activity of Sterculia lychnophora (fruit). The plant material was collected & subjected to extraction by hydroalcoholic solvent. Further, procedures for checking hepatoprotective activity in animals were performed by standard procedures. Results showed that percentage yield was found to be 8.65%. The phytochemical screening presence of alkaloids, glycosides, carbohydrates, tannins, resins, flavonoids, steroids, proteins and amino acids. Total phenol & flavonoid content was found to be 0.758 mg/100mg & 0.822 mg/100mg. The level of AST in rats treated with standard drug was found to be 36.95±0.63 while in rats treated with Hydroalcoholic extract of Sterculia lychnophora it was estimated to be 65±0.35. Further the level of ALP & ALT in Hydroalcoholic extract of Sterculia lychnophora treated rat was noted as 60.50±1.07 & 134.68±1.20. The level of triglyceride in hydroalcoholic extract of Sterculia lychnophora treated rats was seen to be 124.85±0.75. The total cholesterol & bilirubin level was observed to be 158.87±0.50 & 132.36 ± 0.35 respectively in rats treated with plant extract. The findings of this investigation confirm the presence of physiologically active chemicals with hepatoprotective potential in Sterculia lychnophora extracts.

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