FORMULATION AND CHARACTERIZATION OF CLINDAMYCIN LOADED INVASOMES FOR EFFECTIVE TREATMENT OF ACNE
Satya Pratap Singh*, Mr. Santosh Kumar, Mr. Manvendra Singh Kaurav, Dr. Avinash Krishnrao Kondalkar
ABSTRACT
Acne vulgaris is a persistent, inflammatory skin condition that has become more and more burdensome for both sufferers and society. For that TDDS has significantly increases patient compliance and the therapeutic benefit as a whole. Invasomes are flexible nanoscale vesicular systems based on phospholipids that contain terpenes or a combination of terpenes, ethanol, and phosphatidylcholine, and have significantly greater percutaneous permeability. Thus, goal of this study is Formulation and Characterization of Clindamycin Loaded Invasomes for effective treatment of acne. The invasomal gel was formulated & evaluated as per the standard procedure. Results revealed that out of six formulation of invasome the F5 have highest entrapment efficiency of 73.32±0.14 % with vesicle size of 215.65±1.78nm. The zeta potential of F5 estimated to be -35.65. Further three formulations of invasomal gel were made of which highest drug content was observed in G-2 formulation which is 99.45±0.20. The viscosity & pH was observed to be 3312.85±0.35 cps & 6.81±0.15. Also, the extrudability and spreadibility observed to be 172±5±0.23g and 11.36±0.25 g.cm/sec. Additionally, the % Cumulative Drug Release for 12 hr noted to be 99.15 for G-2 formulation. The R2 value was observed to be 0.992 which intended to follow higuchi release kinetics. The formulated invasomal gel observed to be stable for 3 months at 4.0 ±0. 2°C as s the drug content was observed to be 98.32 % also the physical appearance of gel seen to be normal. So, accordingly the formulated invasomal gel of clindamycin can be effectively used to treat acne.
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